The rapid and highly efficient synthesis of hydantoin derivatives 3(a-f) was achieved under microwave irradiation by using a domestic microwave oven from the reactions of cyanohydrin derivatives 2(a-f) with ammonium carbonate. The reaction proceeded rapidly (2-5 min.), and as a result a series of hydantoin derivatives 3(a-f) were obtained in high yields. All of the synthesized compounds were fully characterized by their melting point, ^1H-NMR, FTIR spectroscopy and elemental analyses. Cyanohydrin derivatives 2(a-f) were also prepared from the ketone derivatives 1(a-f) with potassium cyanide in the presence of sodium metabisulfite in an additional reaction.
FAGHIHI, KHALIL; ZAMANI, KHOSROW; and MOBINIKHALEDI, AKBAR (2004) "Facile Synthesis of Hydantoin Derivatives under Microwave Irradiation," Turkish Journal of Chemistry: Vol. 28: No. 3, Article 9. Available at: https://journals.tubitak.gov.tr/chem/vol28/iss3/9