Crosslinked copolymers of various compositions of N-vinyl-2-pyrrolidone (VP) and 2-hydroxyethyl methacrylate (HEMA) were prepared chemically in the presence of a crosslinking agent. The swelling mechanism was non-Fickian with about 86% conversion of feed composition to crosslinked copolymer. The reactivity ratios r_1 = 0.045 and r_2 = 3.07 for VP and HEMA indicate that HEMA is more reactive than VP in the reaction. Hydrophilicity, hydrophobicity and monomer composition in the copolymer controlled the drug release from the hydrogels.
N-vinyl-2-pyrrolidone, 2-hydroxyethyl methacrylate, Hydrogels, Drug release
AHMAD, BASHIR; BASHIR, SHUMAILA; NISA, SHAMS-UN; and HUGLIN, M. B. (2004) "Chemically Crosslinked N-Vinyl-2-Pyrrolidone/2-Hydroxyethyl Methacrylate (VP/HEMA) Copolymer for the Controlled Release of Cyclic Oligopeptide," Turkish Journal of Chemistry: Vol. 28: No. 3, Article 3. Available at: https://journals.tubitak.gov.tr/chem/vol28/iss3/3