Chemically Crosslinked N-Vinyl-2-Pyrrolidone/2-Hydroxyethyl Methacrylate (VP/HEMA) Copolymer for the Controlled Release of Cyclic Oligopeptide

Authors

BASHIR AHMAD
SHUMAILA BASHIR
SHAMS-UN NISA
M. B. HUGLIN

DOI

-

Abstract

Crosslinked copolymers of various compositions of N-vinyl-2-pyrrolidone (VP) and 2-hydroxyethyl methacrylate (HEMA) were prepared chemically in the presence of a crosslinking agent. The swelling mechanism was non-Fickian with about 86% conversion of feed composition to crosslinked copolymer. The reactivity ratios r_1 = 0.045 and r_2 = 3.07 for VP and HEMA indicate that HEMA is more reactive than VP in the reaction. Hydrophilicity, hydrophobicity and monomer composition in the copolymer controlled the drug release from the hydrogels.

Keywords

N-vinyl-2-pyrrolidone, 2-hydroxyethyl methacrylate, Hydrogels, Drug release

First Page

279

Last Page

286

Recommended Citation

AHMAD, BASHIR; BASHIR, SHUMAILA; NISA, SHAMS-UN; and HUGLIN, M. B. (2004) "Chemically Crosslinked N-Vinyl-2-Pyrrolidone/2-Hydroxyethyl Methacrylate (VP/HEMA) Copolymer for the Controlled Release of Cyclic Oligopeptide," Turkish Journal of Chemistry: Vol. 28: No. 3, Article 3. Available at: https://journals.tubitak.gov.tr/chem/vol28/iss3/3