Synthesis and Antimicrobial Activity of Some Pyridyl and Naphthyl Substituted 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives

Authors

KHOSROW ZAMANI
KHALIL FAGHIHI
TARANEH TOFIGHI
MOHAMMAD REZA SHARIATZADEH

DOI

-

Abstract

Synthesis of new 1,2,4-tri and 1,3,4-thiadiazoles, bearing isomeric pyridyl and 1-naphthyl is reported using 1,4-disubstituted thiosemicarbazides in alkaline and acidic media, respectively. The methylthio and benzylthio derivatives of the synthesized triazoles are also reported. All of the synthesized compounds were characterized by their FT-IR, ^{1}H-NMR and mass spectral data. The antibacterial studies of some of the synthesized compounds against S. aureus} and E. coli} as MIC values are reported. None of them have important antibacterial activities.

First Page

95

Last Page

100

Recommended Citation

ZAMANI, KHOSROW; FAGHIHI, KHALIL; TOFIGHI, TARANEH; and SHARIATZADEH, MOHAMMAD REZA (2004) "Synthesis and Antimicrobial Activity of Some Pyridyl and Naphthyl Substituted 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives," Turkish Journal of Chemistry: Vol. 28: No. 1, Article 11. Available at: https://journals.tubitak.gov.tr/chem/vol28/iss1/11