Synthesis and Antimicrobial Activity of Some Pyridyl and Naphthyl Substituted 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives

Authors

KHOSROW ZAMANI
KHALIL FAGHIHI
TARANEH TOFIGHI
MOHAMMAD REZA SHARIATZADEH

Abstract

Synthesis of new 1,2,4-tri and 1,3,4-thiadiazoles, bearing isomeric pyridyl and 1-naphthyl is reported using 1,4-disubstituted thiosemicarbazides in alkaline and acidic media, respectively. The methylthio and benzylthio derivatives of the synthesized triazoles are also reported. All of the synthesized compounds were characterized by their FT-IR, ^{1}H-NMR and mass spectral data. The antibacterial studies of some of the synthesized compounds against S. aureus} and E. coli} as MIC values are reported. None of them have important antibacterial activities.

DOI

-

First Page

95

Last Page

100

Recommended Citation

ZAMANI, K, FAGHIHI, K, TOFIGHI, T, & SHARIATZADEH, M. R (2004). Synthesis and Antimicrobial Activity of Some Pyridyl and Naphthyl Substituted 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives. Turkish Journal of Chemistry 28 (1): 95-100. https://doi.org/-