Synthesis and Analgesic and Anti-Inflammatory Activity of New Pyridazinones

Authors

DENİZ S. DOĞRUER
M. FETHİ ŞAHİN
ESRA KÜPELİ
ERDEM YEŞİLADA

DOI

-

Abstract

A new series of 2-(6-oxo-3,5-diphenyl-6H-pyridazin-1-yl)- acetamides and 3-[6-oxo-3,5-diphenyl-6H-pyridazin-1-yl)-propanamides were synthesized and evaluated in terms of their analgesic and anti-inflammatory activities. All compounds except for 7g were more potent than aspirin in a p-benzoquinone--induced writhing test at 100 mg/kg dose. Compounds 7b, 7c and 7e had the highest anti-inflammatory activity; compound 7e was the most potent in terms of analgesic and anti-inflammatory activities and had no ulcerogenic side effects.

Keywords

6-Oxo-3, 5-diphenylpyridazine, synthesis, spectral analysis, analgesic, anti-inflammatory

First Page

727

Last Page

738

Recommended Citation

DOĞRUER, DENİZ S.; ŞAHİN, M. FETHİ; KÜPELİ, ESRA; and YEŞİLADA, ERDEM (2003) "Synthesis and Analgesic and Anti-Inflammatory Activity of New Pyridazinones," Turkish Journal of Chemistry: Vol. 27: No. 6, Article 9. Available at: https://journals.tubitak.gov.tr/chem/vol27/iss6/9