Synthesis and Analgesic and Anti-Inflammatory Activity of New Pyridazinones

Authors

DENİZ S. DOĞRUER
M. FETHİ ŞAHİN
ESRA KÜPELİ
ERDEM YEŞİLADA

Abstract

A new series of 2-(6-oxo-3,5-diphenyl-6H-pyridazin-1-yl)- acetamides and 3-[6-oxo-3,5-diphenyl-6H-pyridazin-1-yl)-propanamides were synthesized and evaluated in terms of their analgesic and anti-inflammatory activities. All compounds except for 7g were more potent than aspirin in a p-benzoquinone--induced writhing test at 100 mg/kg dose. Compounds 7b, 7c and 7e had the highest anti-inflammatory activity; compound 7e was the most potent in terms of analgesic and anti-inflammatory activities and had no ulcerogenic side effects.

DOI

-

Keywords

6-Oxo-3, 5-diphenylpyridazine, synthesis, spectral analysis, analgesic, anti-inflammatory

First Page

727

Last Page

738

Recommended Citation

DOĞRUER, D. S, ŞAHİN, M. F, KÜPELİ, E, & YEŞİLADA, E (2003). Synthesis and Analgesic and Anti-Inflammatory Activity of New Pyridazinones. Turkish Journal of Chemistry 27 (6): 727-738. https://doi.org/-