Turkish Journal of Chemistry
DOI
-
Abstract
4-Fenoldiazonium tetrafluoroborate and 4-benzoicaciddiazonium tetrafluoroborate was prepared and was shown to be an effective DNA cleavage agent in the presence of the 1-electron donor copper(II) chloride. Its mechanism involves the generation of the aryl radical cleaving DNA by hydrogen atom abstraction from deoxyribose sugar.
Keywords
Aryl radicals, diazonium salts, DNA cleavage
First Page
539
Last Page
544
Recommended Citation
KIZIL, MURAT; YILMAZ, EBRU İNCE; PİRİNÇÇİOĞLU, NECMETTİN; and AYTEKİN, ÇETİN (2003) "DNA Cleavage Activity of Diazonium Salts: Chemical Nucleases," Turkish Journal of Chemistry: Vol. 27: No. 5, Article 1. Available at: https://journals.tubitak.gov.tr/chem/vol27/iss5/1
