4-Fenoldiazonium tetrafluoroborate and 4-benzoicaciddiazonium tetrafluoroborate was prepared and was shown to be an effective DNA cleavage agent in the presence of the 1-electron donor copper(II) chloride. Its mechanism involves the generation of the aryl radical cleaving DNA by hydrogen atom abstraction from deoxyribose sugar.
Aryl radicals, diazonium salts, DNA cleavage
KIZIL, MURAT; YILMAZ, EBRU İNCE; PİRİNÇÇİOĞLU, NECMETTİN; and AYTEKİN, ÇETİN (2003) "DNA Cleavage Activity of Diazonium Salts: Chemical Nucleases," Turkish Journal of Chemistry: Vol. 27: No. 5, Article 1. Available at: https://journals.tubitak.gov.tr/chem/vol27/iss5/1