DNA Cleavage Activity of Diazonium Salts: Chemical Nucleases

Authors

MURAT KIZIL
EBRU İNCE YILMAZ
NECMETTİN PİRİNÇÇİOĞLU
ÇETİN AYTEKİN

DOI

-

Abstract

4-Fenoldiazonium tetrafluoroborate and 4-benzoicaciddiazonium tetrafluoroborate was prepared and was shown to be an effective DNA cleavage agent in the presence of the 1-electron donor copper(II) chloride. Its mechanism involves the generation of the aryl radical cleaving DNA by hydrogen atom abstraction from deoxyribose sugar.

Keywords

Aryl radicals, diazonium salts, DNA cleavage

First Page

539

Last Page

544

Recommended Citation

KIZIL, MURAT; YILMAZ, EBRU İNCE; PİRİNÇÇİOĞLU, NECMETTİN; and AYTEKİN, ÇETİN (2003) "DNA Cleavage Activity of Diazonium Salts: Chemical Nucleases," Turkish Journal of Chemistry: Vol. 27: No. 5, Article 1. Available at: https://journals.tubitak.gov.tr/chem/vol27/iss5/1