Synthesis of New 4-(5-Chloro-2-oxo-3H-benzoxazol-3-yl)butanamide Derivatives and Their Analgesic and Anti-Inflammatory Properties

Authors

H. OZAN GÜLCAN
SERDAR ÜNLÜ
ERDEN BANOĞLU
M. FETHİ ŞAHİN
ESRA KÜPELİ
ERDEM YEŞİLADA

DOI

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Abstract

In this preliminary screening study for developing potent analgesic and anti-inflammatory compounds, eight new 4-(5-chloro-2-oxo-3H-benzoxazol-3-yl)butanamide derivatives were synthesized and screened for their analgesic and anti-inflammatory activities as well as gastric ulceration potential in tested animals. Their structures were elucidated by their IR, ^{1}H-NMR and elemental analysis. All of the compounds exhibited high analgesic and anti-inflammatory activities. None of the compounds except compound 2g caused gastric lesions or bleeding in tested animals.

Keywords

2-Oxo-3H-benzoxazole, butanamide, analgesic, anti-inflammatory, COX-1, COX-2.

First Page

467

Last Page

476

Recommended Citation

GÜLCAN, H. OZAN; ÜNLÜ, SERDAR; BANOĞLU, ERDEN; ŞAHİN, M. FETHİ; KÜPELİ, ESRA; and YEŞİLADA, ERDEM (2003) "Synthesis of New 4-(5-Chloro-2-oxo-3H-benzoxazol-3-yl)butanamide Derivatives and Their Analgesic and Anti-Inflammatory Properties," Turkish Journal of Chemistry: Vol. 27: No. 4, Article 7. Available at: https://journals.tubitak.gov.tr/chem/vol27/iss4/7