Synthesis of New Antimicrobial Agents; Amide Derivatives of Pyranones and Pyridinones

Authors

MUTLU DİLSİZ AYTEMİR
ROBERT C. HIDER
DİLEK DEMİR EROL
MERAL ÖZALP
MELİKE EKİZOĞLU

DOI

-

Abstract

In this study, 4(1H)-pyridinones with an amide function in Position 2 of the pyridinone ring showed antimicrobial activity. The synthesis and the biological properties of some novel amide derivatives of pyran-4(1H)-one and 4(1H)-pyridinone have been reported. Amide derivatives of pyran-4(1H)-one and 4(1H)-pyridinone were prepared using two different methods. Antimicrobial activities were determined as MIC values using the microdilution broth method against the bacteria Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Pseudomonas aeruginosa and the fungi Candida albicans, Candida krusei and Candida parapsilosis. Compounds 6 and 9 exhibited the best inhibitor activity against S. aureus.

Keywords

Pyran-4(1H)-one, 4(1H)-pyridinone, antibacterial activity, antifungal agents.

First Page

445

Last Page

452

Recommended Citation

AYTEMİR, MUTLU DİLSİZ; HIDER, ROBERT C.; EROL, DİLEK DEMİR; ÖZALP, MERAL; and EKİZOĞLU, MELİKE (2003) "Synthesis of New Antimicrobial Agents; Amide Derivatives of Pyranones and Pyridinones," Turkish Journal of Chemistry: Vol. 27: No. 4, Article 4. Available at: https://journals.tubitak.gov.tr/chem/vol27/iss4/4