Bisabolane Type Sesquiterpenes from a Marine Didiscus Sponge

Authors

DENİZ TAŞDEMİR
TIMOTHY S. BUGNI
GINA C. MANGALINDAN
GISELA P. CONCEPCION
MARY KAY HARPER
CHRIS M. IRELAND

Abstract

Two bisabolane type sesquiterpene phenols, (+)-curcuphenol (1) and (+)-curcudiol (2), were isolated from a Philippine marine sponge, Didiscus sp., in addition to \beta -sitosterol (3) and phenethylamine (4). The structures of the metabolites were established on the basis of spectral evidence (1D- and 2D NMR, [\alpha]_{D}, EIMS). (+)-Curcuphenol (1) showed cytotoxicity, which is indicative of a p53 independent mechanism.

DOI

-

Keywords

Marine sponge, Didiscus, (+)-curcuphenol, (+)-curcudiol, \beta -sitosterol, phenethylamine, HCT-116

First Page

273

Last Page

279

Recommended Citation

TAŞDEMİR, D, BUGNI, T. S, MANGALINDAN, G. C, CONCEPCION, G. P, HARPER, M. K, & IRELAND, C. M (2003). Bisabolane Type Sesquiterpenes from a Marine Didiscus Sponge. Turkish Journal of Chemistry 27 (2): 273-279. https://doi.org/-