Turkish Journal of Chemistry
DOI
-
Abstract
A new spectrophotometric method based on the formation of an ion-pair using bromothymol blue as ion-pair complexing reagent was developed for the determination of mexiletine hydrochloride in capsules. The ion-pair formed was highly coloured and easily extracted with dichloromethane. The calibration curve was linear over the concentration range 1.08--10.8 \mu g.ml^{-1} at \lambda_{max} = 408 nm (r = 0.9999). The results obtained from the developed method were compared statistically with those obtained by the British Pharmacopeia method.
Keywords
Spectrophotometry, Mexiletine hydrochloride, Bromothymol blue, Ion-pair.
First Page
839
Last Page
842
Recommended Citation
AYDOĞMUŞ, ZEYNEP; ÇETİN, S. MÜGE; and TOSUNOĞLU, SEDAT (2002) "Spectrophotometric Determination of Mexiletine Hydrochloride in Capsules Using Bromothymol Blue," Turkish Journal of Chemistry: Vol. 26: No. 6, Article 5. Available at: https://journals.tubitak.gov.tr/chem/vol26/iss6/5
