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Turkish Journal of Chemistry

Authors

M. LEVENT ALTUN

DOI

-

Abstract

An accurate, simple, reproducible and sensitive method for the determination of paracetamol, caffeine and dipyrone was developed and validated. Paracetamol, caffeine and dipyrone were separated using a \mu -Bondapack C _{8} column by isocratic elution with a flow rate of 1.0 ml/min. The mobile phase composition was 0.01 M KH_2PO_{4-} -methanol-acetonitrile-isopropyl alcohol (420: 20: 30: 30) (v/v/v/v) and spectrophotometric detection was carried out at 215 nm. The linear range of determination for paracetamol, caffeine and dipyrone were 0.409-400 \mu g/ml, 0.151-200 \mu g/ml and 0.233-600 \mu g/ml, respectively. The method was shown to be linear, reproducible, specific, sensitive and rugged.

First Page

521

Last Page

528

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