Turkish Journal of Chemistry
DOI
-
Abstract
The construction and performance characteristics of ion-selective membrane electrodes for a newly found phenylpiperazine antidepressant, Nefazodone (NFN), based on its ion-pair complexes with phosphotungstate (PT), tetraphenylborate (TPB), tungstosilicate (TS) and reineckate (RN) in a poly(vinyl chloride) (PVC) matrix are described. The best ion-selective electrode for determination of NFN contains NFN-PT as the active material. This electrode exhibits a Nernstian response (62.6 ± 0.4 mV per decade) in the range 1.5 x 10$^{-5}$ to 1.0 x 10^{-2} M NFN.HCl in solutions. The selectivity of this electrode to NFN in the presence of a number of sugar molecules, cations and drugs is reported. The potentiometric standard addition method and the argentometric titration method are used to determine the NFN amount in pure solution.
First Page
353
Last Page
360
Recommended Citation
ERDEM, ARZUM; ÖZKAN, DİLŞAT; KERMAN, KAĞAN; MERİÇ, BURCU; DALBASTI, TAYFUN; and ÖZSÖZ, MEHMET (2000) "Ion-Selective Membrane Electrode for the Determination of a Novel Phenylpiperazine Antidepressant, Nefazodone," Turkish Journal of Chemistry: Vol. 24: No. 4, Article 5. Available at: https://journals.tubitak.gov.tr/chem/vol24/iss4/5
