Turkish Journal of Chemistry
Abstract
The construction and performance characteristics of ion-selective membrane electrodes for a newly found phenylpiperazine antidepressant, Nefazodone (NFN), based on its ion-pair complexes with phosphotungstate (PT), tetraphenylborate (TPB), tungstosilicate (TS) and reineckate (RN) in a poly(vinyl chloride) (PVC) matrix are described. The best ion-selective electrode for determination of NFN contains NFN-PT as the active material. This electrode exhibits a Nernstian response (62.6 ± 0.4 mV per decade) in the range 1.5 x 10$^{-5}$ to 1.0 x 10^{-2} M NFN.HCl in solutions. The selectivity of this electrode to NFN in the presence of a number of sugar molecules, cations and drugs is reported. The potentiometric standard addition method and the argentometric titration method are used to determine the NFN amount in pure solution.
DOI
-
First Page
353
Last Page
360
Recommended Citation
ERDEM, ARZUM; ÖZKAN, DİLŞAT; KERMAN, KAĞAN; MERİÇ, BURCU; DALBASTI, TAYFUN; and ÖZSÖZ, MEHMET (2000) "Ion-Selective Membrane Electrode for the Determination of a Novel Phenylpiperazine Antidepressant, Nefazodone," Turkish Journal of Chemistry: Vol. 24: No. 4, Article 5. Available at: https://journals.tubitak.gov.tr/chem/vol24/iss4/5
