Preparation of Optically Active Amino Acid Derivatives of Some Methylated 5-Amino-Azaheterocycles

Authors

MASHOODA HASAN
FARZANA SHAHEEN
UZMA YUNUS
SHAZIA MUNIR

DOI

-

Abstract

The present paper describes the reduction of 1-methyl-5-nitro-benzimidazoles ({\bf 1A, 2A}) and 1,3-dimethyl-2H-5-nitro-benzimidazol-2-one ({\bf 3}) to 5-aminobenzimidazoles ({\bf 4A, 5A}) and 1,3-dimethyl-2H-5-amino-benzimidazol-2-one ({\bf 6}) respectively with hydrazine hydrate in absolute ethanol in the presence of graphite. Compounds {\bf 5A} and {\bf 6} were converted to 2-ethyl-5-(phthaloyl-L-phenylalanyl)amino-1-methylbenzimidazole ({\bf 7}) and 1,3-dimethyl-5-(phthaloyl-L-phenylalanyl)aminobenzimidazol-2-one ({\bf 8}). Characterization of the synthesized compounds was done with the help of mass spectrometry and ^1H NMR spectroscopic studies. Optical activity of the amino acid derivatives {\bf 7} and {\bf 8} was also recorded.

First Page

165

Last Page

176

Recommended Citation

HASAN, MASHOODA; SHAHEEN, FARZANA; YUNUS, UZMA; and MUNIR, SHAZIA (2000) "Preparation of Optically Active Amino Acid Derivatives of Some Methylated 5-Amino-Azaheterocycles," Turkish Journal of Chemistry: Vol. 24: No. 2, Article 7. Available at: https://journals.tubitak.gov.tr/chem/vol24/iss2/7