Turkish Journal of Chemistry
Transition Metal Compound Mediated Reduction of \alpha-Amino Acids to 1,2-Amino Alcohols with NaBH_4 in Water
A new efficient and cost-effective method for the preparation of 1,2-amino alcohols is described. The reactions of amino acids with NaBH_4 in the presence of NiCl_2 or MoO_3 in water give 1,2-amino alcohols in high yield. When optically pure amino acids were used, optically pure 1,2-amino alcohols were obtained.
DEMİR, AYHAN S.; AKHMEDOV, İDRIS M.; and ŞEŞENOĞLU, ÖZGE (1999) "Transition Metal Compound Mediated Reduction of \alpha-Amino Acids to 1,2-Amino Alcohols with NaBH_4 in Water," Turkish Journal of Chemistry: Vol. 23: No. 2, Article 2. Available at: https://journals.tubitak.gov.tr/chem/vol23/iss2/2