•  
  •  
 

Turkish Journal of Chemistry

DOI

-

Abstract

This study describes the optimal conditions for the determination of Thioridazine HCl (Tz-HCl) in 0.2 M sulphuric acid by voltammetry using ruthenium (Ru), platinum (Pt) and glassy carbon (GC) electrodes. A new and sensitive method is described for electrochemical determination of Tz-HCl in the concentration range $5.10^{-5} - 10^{-3}$ M (20.35-407 $\mu$gml$^{-1}$); $6.10^{-4} - 10^{-2}$ M (244.2 - 4070 $\mu$gml$^{-1}$); $10^{-4} - 10^{-3}$ M (40,7 - 407 $\mu$gml$^{-1}$), with Ru, Pt and glassy carbon electrodes, respectively. The method was applied successfully to the determination of Tz-HCl in pure form or incorporated in their representative pharmaceutical preparations. The precision of the assay was comparable with that of the official assays.

First Page

325

Last Page

334

Included in

Chemistry Commons

Share

COinS