Turkish Journal of Chemistry
DOI
-
Abstract
Electronic changes of iron- and metal free porphyrins are reviewed in light of their importance to modify the ferri/ferro reduction potential and energy dissipation between ligated carbon monoxide and the porphyrin chelate. Substitutions at positions 2 and 4 are effective ways to exercise this influence. Other measures include exposure to water and modifications of axial ligation, including the \lq three-ligand' case. These measures will also influence the stability of recombined hemin-protein entities, as apparent from the kinetics of heme-transfer from a modified donor protein to apomyoglobin, but the stability appears to be related to the bulkiness of 2,4-substitutional groups rather than to electron availability. It is suggested that the altered stability is a secondary effect from enhanced exposure to water in the crevice.
First Page
103
Last Page
108
Recommended Citation
PAUL, Jan; CHEN, Wenhua; OHLSSON, Per-Ingvar; and SMITH, Michael (1998) "Heme Transfer Reactions: An Important Prerequisite for Synthetic Oxygen Carriers," Turkish Journal of Chemistry: Vol. 22: No. 2, Article 2. Available at: https://journals.tubitak.gov.tr/chem/vol22/iss2/2
