Turkish Journal of Chemistry
DOI
-
Abstract
A complete synthesis of 2[1'(3', 5'-disubstituted pyrazolyl) methyl] 5- phenyl-1,3,4-thiadiazole V(a-b) and 1,2,4-trizole VI (a-b) is reported. Cyclocondensation of \beta-diketones with etylhydrazino acetate hydrochloride yielded ethyl 3,5-disubstituted pyrazolyl acetate II(a-c) which on treatment with hydrazine hydrate resulted in the formation of their hydrazide derivatives III(a-c). These hydrazides, when treated with phenyl isothiocyanate, gave thiosemicarbazide derivatives IV(a-c), which were cyclised in the presence of con. H_{2}SO_{4} and NaOH to give V(a-b) and VI(a-b), respectively.
First Page
186
Last Page
193
Recommended Citation
AHMAD, Roshan; ZIA-UL-HAQ, M.; JABEEN, Rukhsana; and DUDDECK, Helmut (1996) "Synthesis of 2[1'(3',5'-Disubstituted Pyrazolyl) Methyl]5-Phenyl Amino-1,3,4-Thiadiazoles and 1,2,4-Triazoles as Potential Therapeutic Agents," Turkish Journal of Chemistry: Vol. 20: No. 3, Article 2. Available at: https://journals.tubitak.gov.tr/chem/vol20/iss3/2
