Abstract

Oral anticoagulant Warfarin (4-hydroxy-3-(3-oxo-1-phenyl butyl)-2H-1- benzopyran-2-one) is synthesized in optically active form starting from 4- hydroxycoumarin via formation of optically active enamines followed by Michael addition reaction with benzyliden acetone at low temperature. Different amines gave 17-68\% ee and the chemical yield was 22-71\%, depending on the reaction conditions and the structure of chiral amines.

DOI

First Page

139

Last Page

145

Recommended Citation

DEMİR, A. S, TANYELi, C, GÜLBEYAZ, V, & AKGÜN, H (1996). Enantioselective Synthesis of 4-Hydroxy-3-(3-Oxo-1-Phenyl Butyl)- 2H-1-Benzopyran-2-One (Warfarin). Turkish Journal of Chemistry 20 (2): 139-145. https://doi.org/-

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