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Turkish Journal of Biology

Abstract

Background/aim: In an aging model established in male Wistar albino rats via the administration of D-galactose (D-gal), the aim of this study was to examine the effects of chelidonic acid on cognitive functioning and the levels of glutathione (GSH), malondialdehyde (MDA), Total antioxidant status (TAS), and brain-derived neurotrophic factor (BDNF).Materials and methods: Thirty-two Wistar albino (three month old) male rats (n = 8) were used. Group 1: Control (C), Group 2: Chelidonic acid (CA) (2 mg/kg oral gavage), Group 3: D-galactose (D-gal) (150 mg/kg, s.c.), Group 4: D-gal (150 mg/kg) + CA (2 mg/kg) (DC). Following an overnight fast, the 10-week trial was concluded with intramuscular injections of the anesthetic drugs Xylazine (8–10 mg/kg) and Ketamine (80–100 mg/kg), subsequently the collection of cardiac blood. The rats' brain tissues were taken out. GSH, MDA, TAS, and BDNF quantities were determined in the collected serum samples and prepared tissue homogenates. Novel Object Recognition and Morris Water Tank experiments were also used to evaluate cognitive functions. GraphPad was used to conduct ANOVA-LSD tests for statistical analysis. Every data point was presented as mean ± standard error, with significance being determined at p< 0.05 levels.Results: Comparing the D-galactose group to the D-gal + CA group, the former demonstrated a statistically significant improvement in the discrimination index for memory in both the short and long term. Further analysis of the Morris Water Maze data for these groups indicated a notable drop in the amount of time required for finding the platform. In comparison with the D-gal group, it was observed that MDA levels dropped in the CA and D-gal + CA groups, whereas GSH, TAS, and BDNF levels increased in both serum and hippocampus samples.Conclusion: These findings suggest that CA could effectively contribute to addressing age-related neurological disorders.

Author ORCID Identifier

FERİDE SİNAN: 0009-0009-9057-6575

EMEL SERDAROĞLU KAŞIKÇI: 0000-0003-1566-5788

BURCU ÇEVRELİ: 0000-0001-6337-4999

DOI

10.55730/1300-0152.2717

Keywords

Aging, chelidonic acid, D-galactose, antioxidant, memory

First Page

432

Last Page

441

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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