Turkish Journal of Biology
Design and in vitro, in vivo evaluation of antioxidant bioadhesive gelsfor burn treatment
Burn wounds are frequently encountered health problems, which need a new treatment approach especially in terms of good patient compliance. Availability of use of antioxidant agents and bio-adhesive gels in tissue healing can be an alternative as a new approach for wound healing. Antioxidant taurine containing bio-adhesive gels were prepared by using carbopol (CP) 940 and 934. Rheological and texture analyses were carried out on bio-adhesive gels for in vitro characterization. Wound model on Wistar rats was used to evaluate the in vivo evaluation of gels. Rheological and texture analyses showed that a carbopol bioadhesive gel has acceptable topically use dosage characteristics and in combination with Taurine it presented a successful wound healing effect via antioxidant parameters. In conclusion, bio-adhesive CP 940 (2%) gel containing 50 mM taurine could be promising in the treatment of burns by balancing oxidative stress.
Taurine, antioxidant, bio-adhesive gel, burn wound model
GÖKÇE, GÖKSEL; KARAVANA, SİNEM YAPRAK; BAĞRIYANIK, HÜSNÜ ALPER; PEKÇETİN, ÇETİN; YAPAR, EVREN ALĞIN; TURAL, GÜLŞEN AYBAR; and GÖKÇE, EVREN HOMAN
"Design and in vitro, in vivo evaluation of antioxidant bioadhesive gelsfor burn treatment,"
Turkish Journal of Biology: Vol. 46:
3, Article 6.
Available at: https://journals.tubitak.gov.tr/biology/vol46/iss3/6