Turkish Journal of Biology
Abstract
The hepatitis C virus (HCV) infection is a significant cause of morbidity and mortality worldwide. Infection with HCV becomes chronic in more than 80% of cases and it accounts for 20% of all cases of acute hepatitis. The hepatitis C virus was first identified by the molecular cloning of the virus genome in 1989. It is an enveloped, positive strand RNA virus with a genome size of around 9.5 kilobases. The single-stranded RNA genome of the virus contains a large open reading frame that encodes a large polyprotein of 3,010 to 3,033 amino acids shown to be processed by a combination of host and viral proteinases to produce at least ten proteins post-translationally. The proteins that are closer to the amino terminal of the polyprotein are termed structural and the rest, closer to the carboxy terminal, are called nonstructural (NS) proteins.
DOI
-
First Page
253
Last Page
270
Recommended Citation
EROĞLU, ÇAĞLA and PINARBAŞI, ERGÜN (2000) "Hepatitis C Virus: Genome Organization, ViralProteins and Implications in Disease Pathogenesis," Turkish Journal of Biology: Vol. 24: No. 2, Article 8. Available at: https://journals.tubitak.gov.tr/biology/vol24/iss2/8
