Improving the water solubility of cannabidiol using a peptide carrier

Authors

MELEK PARLAK KHALILYFollow

Author ORCID Identifier

0000-0002-5402-0467

DOI

10.55730/1300-0527.3655

Abstract

Cannabidiol (CBD), nonpsychotropic cannabinoid found in Cannabis sativa, is a very promising drug candidate offering many differential effects such as sedative, antiinflammatory, antioxidant, and neuroprotective properties. Nevertheless, the therapeutic use of CBD is hindered by its lack of water solubility and relatively low bioavailability. Various carriers have been used to address the solubility issues of CBD and other highly lipophilic drugs so far. However, self-assembled peptide nanostructures as carrier have not been used to improve the water solubility of CBD yet. In this study, a self-assembling peptide micelle was demonstrated to be an effective vehicle for encapsulation of CBD and increased its aqueous solubility up to 2000-fold compared to CBD itself.

Keywords

Cannabidiol, self-assembling peptides, solubility, encapsulation, cannabis

First Page

229

Last Page

236

Recommended Citation

PARLAK KHALILY, MELEK (2024) "Improving the water solubility of cannabidiol using a peptide carrier," Turkish Journal of Chemistry: Vol. 48: No. 2, Article 4. https://doi.org/10.55730/1300-0527.3655
Available at: https://journals.tubitak.gov.tr/chem/vol48/iss2/4