Synthesis and biological properties of novel1-methyl-2-(2-(prop-2-yn-1-yloxy)benzylidene) hydrazine analogues

Authors

ARİF KIVRAK
CAN YILMAZ
METİN KONUŞ
HALİL KOCA
SELAHATTİN AYDEMİR
JEGER ALI OAGAZ

DOI

10.3906/kim-1701-42

Abstract

1-Methyl-2-(2-(prop-2-yn-1-yloxy)benzylidene)hydrazine analogues were readily prepared in good yields by the reaction of 2-(prop-2-yn-1-yloxy)benzaldehydes and methyl hydrazine. The reaction tolerates a variety of substituents on the 2-hydroxybenzaldehyde to form nitro-, halo-, methoxy-, and naphthyl-substituted 1-methyl-2-(2-(prop-2-yn-1-yloxy)benzylidene)hydrazines. The in vitro antioxidant capacity measurements revealed that among all the analyzed hydrazine analogues that surpassed the Trolox standard, 1-(2-(but-3-ynyl)-5-nitrobenzylidene)-2-methylhydrazine had the maximum value, which was approximately 1.7 times that of Trolox.

Keywords

Hydrazines, hydrazones, ABTS, antioxidant capacities, biological properties

First Page

306

Last Page

316

Recommended Citation

KIVRAK, ARİF; YILMAZ, CAN; KONUŞ, METİN; KOCA, HALİL; AYDEMİR, SELAHATTİN; and OAGAZ, JEGER ALI (2018) "Synthesis and biological properties of novel1-methyl-2-(2-(prop-2-yn-1-yloxy)benzylidene) hydrazine analogues," Turkish Journal of Chemistry: Vol. 42: No. 2, Article 9. https://doi.org/10.3906/kim-1701-42
Available at: https://journals.tubitak.gov.tr/chem/vol42/iss2/9