Synthesis, anticandidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chains

Authors

LEYLA YURTTAŞ
YUSUF ÖZKAY
FATİH DEMİRCİ
GAMZE GÖGER
ŞAFAK ULUSOYLAR YILDIRIM
USAMA ABU MOHSEN
ÖMER ÖZTÜRK
ZAFER ASIM KAPLANCIKLI

DOI

10.3906/kim-1312-62

Abstract

Some thiazole derivatives bearing dithiocarbamic acid esters were synthesized in order to investigate their anticandidal activity and cytotoxicity. The structures of the obtained final compounds (6a--j) were confirmed by spectral data (IR, ^1H NMR, ^{13}C NMR, and MS) and elemental analysis. The anticandidal activity of the compounds was determined (6a--j) using the microbroth dilution method and their cytotoxicity was evaluated according to the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay against normal cells. Contrary to expectations, weak antifungal activity was observed with IC_{50} values ranging between 30 and 403 \mu g/mL.

Keywords

Thiazole, dithiocarbamate, anticandidal activity, cytotoxicity

First Page

815

Last Page

824

Recommended Citation

YURTTAŞ, LEYLA; ÖZKAY, YUSUF; DEMİRCİ, FATİH; GÖGER, GAMZE; YILDIRIM, ŞAFAK ULUSOYLAR; MOHSEN, USAMA ABU; ÖZTÜRK, ÖMER; and KAPLANCIKLI, ZAFER ASIM (2014) "Synthesis, anticandidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chains," Turkish Journal of Chemistry: Vol. 38: No. 5, Article 13. https://doi.org/10.3906/kim-1312-62
Available at: https://journals.tubitak.gov.tr/chem/vol38/iss5/13