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Turkish Journal of Chemistry

DOI

-

Abstract

A series of acetic acid derivatives (2a-c) was synthesized by the condensation of compounds 1a-c with chloroacetic acid. The treatment of carboxylic acid derivatives with thiosemicarbazide in phosphorus oxychloride and subsequent diazotation of the products (3a-c) afforded 5-alkyl-2-[(5-chloro-1,3,4-thiadiazol-2-yl)methyl]- 2,4-dihydro-3H-1,2,4-triazol-3-one derivatives (4a-c). The treatment of compounds 4a-c with thiourea produced 5-alkyl-2-[(5-mercapto-1,3,4- thiadiazol-2-yl)methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one derivatives (5a-c). Subsequently, compounds 5a-c were converted to acid hydrazides by treatment with hydrazine hydrate after esterification (7a-e). Moreover, the reaction of compounds 7a-c with carbon disulfite in the presence of KOH afforded 5-alkyl-2-[(5-\{[(5- mercapto-1,3,4-oxadiazol-2-yl)methyl]thio\}-1,3,4-thiadiazol-2-yl)methyl]- 2,4-dihydro-3H-1,2,4-triazol-3-ones (8a-c).

Keywords

1, 2, 4-triazol-3-one 1, 3, 4-thiadiazole, 1, 3, 4-oxadiazole, thiosemicarbazide, diazotation, deamination

First Page

125

Last Page

133

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