Protein fold classification with Grow-and-Learn network

Authors

ÖZLEM POLAT
ZÜMRAY DOKUR

DOI

10.3906/elk-1506-126

Abstract

Protein fold classification is an important subject in computational biology and a compelling work from the point of machine learning. To deal with such a challenging problem, in this study, we propose a solution method for the classification of protein folds using Grow-and-Learn (GAL) neural network together with one-versus-others (OvO) method. To classify the most common 27 protein folds, 125 dimensional data, constituted by the physicochemical properties of amino acids, are used. The study is conducted on a database including 694 proteins: 311 of these proteins are used for training and 383 of them for testing. Overall, the classification system achieves 81.2% fold recognition accuracy on the test set, where most of the proteins have less than 25% sequence identity with the ones used during the training. To portray the capabilities of the GAL network among the other methods, comparisons between a few approaches have also been made, and GAL's accuracy is found to be higher than those of the existing methods for protein fold classification.

Keywords

Protein fold classification, grow and learn neural network, attributes for protein fold recognition, bioinformatics

First Page

1184

Last Page

1196

Recommended Citation

POLAT, ÖZLEM and DOKUR, ZÜMRAY (2017) "Protein fold classification with Grow-and-Learn network," Turkish Journal of Electrical Engineering and Computer Sciences: Vol. 25: No. 2, Article 42. https://doi.org/10.3906/elk-1506-126
Available at: https://journals.tubitak.gov.tr/elektrik/vol25/iss2/42