Understanding and comparison of different drug delivery formulations are based on pharmacokinetic parameters (PKP) such as area under curve, maximum concentration, and time to reach maximum concentration. Accurate estimation of PKP is of critical importance in capturing drug absorption and elimination characteristics and in reaching bioequivalence decisions. Since PKP are estimated from a limited number of samples, the timing of the samples directly influences the accuracy of estimation. Optimization of the sampling times may not only increase the accuracy of PKP estimation, but also reduce the number of samples to be drawn, which in turn lessens the inconvenience to the subjects and the cost of the study. In this study, as an alternative to conventional piece-wise linear approximation, we proposed cubic spline approximation to the time-concentration curve and also introduced a global optimality criterion that focuses on the closeness of all the pharmacokinetic parameter estimators to their true values simultaneously. By minimizing the criterion function over sampling times and watching the regulatory practice/guidance for sample collection, we designed optimal sampling times that can be used in pharmacokinetic studies. We demonstrated that using our approach it is possible to obtain more accurate estimates of PKP with fewer samples.
Pharmacokinetic parameters, optimal sampling time design, spline approximation, sequential quadratic programming
ASYALI, MUSA HAKAN
"Design of optimal sampling times for pharmacokinetic trials via spline approximation,"
Turkish Journal of Electrical Engineering and Computer Sciences: Vol. 18:
6, Article 7.
Available at: https://journals.tubitak.gov.tr/elektrik/vol18/iss6/7