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Turkish Journal of Biology

Abstract

Background/aim: Delayed wound healing in diabetic patients is a significant complication that reduces quality of life, prompting the continuous investigation of new therapeutic agents. This study designed to explore the dose-dependent effects of different parts of Chelidonium majus L. (CM), a medicinal plant traditionally used for skin disorders, on diabetic skin wounds.

Materials and methods: In diabetic rats, full-thickness excisional wounds were formed. CM-containing gels (aerial parts at 3%, 6%, 9% and root at 0.5%, 1%, 1.5%) were developed and applied to the wounds. After the treatment period, the rats were sacrificed, and wound healing activity was assessed macroscopically, histopathologically, and biochemically.

Results: The CM-containing gels (aerial parts or root) accelerated wound closure and increased collagen, glutathione (GSH), and ascorbic acid (AA) content. Additionally, these gels reduced oxidative stress markers, and interleukin-1β (IL-1β) and IL-13 levels, while modulating the activities of matrix metalloproteinase-2 (MMP-2) and MMP-9.

Conclusion: CM accelerates the healing process by increasing antioxidant capacity and modulating MMP activity, and it may have dose-dependent effectiveness in diabetic wound management.

Author ORCID Identifier

KAAN KALTALIOĞLU: 0000-0002-4995-2657

ELİF NAZ GÜRSOY: 0000-0003-4946-1185

BARBAROS BALABANLI: 0000-0002-6670-8904

ZEKİ AYTAÇ: 0000-0003-3244-3183

ŞULE COŞKUN CEVHER: 0000-0001-6204-2845

DOI

10.55730/1300-0152.2757

Keywords

Chelidonium majus, diabetic wound healing, MMPs, phytotherapy, oxidative events

First Page

409

Last Page

420

Publisher

The Scientific and Technological Research Council of Türkiye (TÜBİTAK)

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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