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Turkish Journal of Biology

Abstract

Aim: Neuronal cell death plays a critical role in the development of neurological disorders associated with aging. This study aimed to evaluate the beneficial effects of heat-killed lactic acid bacteria (hkLAB) on neuroblastoma cells and Caenorhabditis elegans.

Materials and methods: We pretreated heat-killed Lactobacillus fermentum CNU384 (hkCNU384), L. brevis CNU386 (hkCNU386), L. helveticus CNU395 (hkCNU395), and L. paracasei CNU396 (hkCNU396) at a concentration of 109 CFU/mL to investigate their neuroprotective effects on glutamate-induced SH-SY5Y cells and their impact on the lifespan of 6-hydroxydopamine (6-OHDA)-induced C. elegans.

Results: Our findings indicate that hkCNU395 and hkCNU396 protected against glutamate-induced cell death via modulation of the Bax/Bcl-2 apoptosis regulator ratio and enhancement of endogenous antioxidant enzyme activity. Moreover, hkCNU396 significantly improves survival rates in C. elegans with neuron degeneration induced by 6-OHDA.

Conclusion: These results highlight hkCNU396 as a promising paraprobiotic candidate for patients suffering from degenerative neurodegenerative diseases.

Author ORCID Identifier

BAO LE: 0000-0001-6037-0546

THI NHAT HONG NGUYEN: 0009-0006-0550-6272

SEUNG-HWAN YANG: 0000-0003-0603-2209

DOI

10.55730/1300-0152.2755

Keywords

Antioxidant, Caenorhabditis elegans, lactic acid bacteria, neurological disorders, paraprobiotic

First Page

392

Last Page

399

Publisher

The Scientific and Technological Research Council of Türkiye (TÜBİTAK)

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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