The cumulative effect of ellagic acid and carnosic acid attenuates oxidative events during diabetic wound healing: in different applications and on different days

Authors

ELİF NAZ GÜRSOYFollow
KANUNİ BARBAROS BALABANLIFollow
FATMA NUR TUĞCU DEMİRÖZFollow
ŞULE COŞKUN CEVHERFollow

Abstract

Background/aim: The hyperglycemic environment in diabetes disrupts normal wound-healing processes, leading to chronic wounds. This study investigated whether the combination of the phenolic compounds Ellagic acid and Carnosic acid shows synergistic effects on diabetic wound healing and oxidative parameters in diabetic rats.Materials and methods: In this study, diabetic rats were divided into control, untreated, Carbopol 974P treated, topical treatment, and oral gavage treatment. Ellagic acid and Carnosic acid combination were applied topically and oral gavage to the full-thickness excisional wounds of all animals except the control group. We investigated oxidative events by malondialdehyde, glutathione, nitric oxide, protein carbonyl, collagen spectrophotometrically, matrix metalloproteinase 2 and 9, and advanced oxidation protein product levels by ELISA method.Results: The combination of Ellagic acid and Carnosic acid decreased malondialdehyde, nitric oxide, protein carbonyl, advanced oxidation protein product, and metalloproteinase 9 levels and increased the rate of wound contraction and collagen levels in the diabetic wound healing model.Conclusion: The combined use of Ellagic acid and Carnosic acid showed a synergistic effect, enhanced wound healing, and decreased oxidative stress. Double therapy of Ellagic acid and Carnosic acid may be an effective therapy for chronic non-healing wounds that occur as a complication of diabetes.

Author ORCID Identifier

ELİF NAZ GÜRSOY: 0000-0003-4946-1185

KANUNİ BARBAROS BALABANLI: 0000-0002-6670-8904

FATMA NUR TUĞCU DEMİRÖZ: 0000-0002-9468-3329

ŞULE COŞKUN CEVHER: 0000-0001-6204-2845

DOI

10.55730/1300-0152.2712

Keywords

Diabetic wound healing, carnosic acid, ellagic acid, matrix metalloproteinase, protein carbonyl

First Page

364

Last Page

378

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

GÜRSOY, ELİF NAZ; BALABANLI, KANUNİ BARBAROS; TUĞCU DEMİRÖZ, FATMA NUR; and COŞKUN CEVHER, ŞULE (2024) "The cumulative effect of ellagic acid and carnosic acid attenuates oxidative events during diabetic wound healing: in different applications and on different days," Turkish Journal of Biology: Vol. 48: No. 6, Article 3. https://doi.org/10.55730/1300-0152.2712
Available at: https://journals.tubitak.gov.tr/biology/vol48/iss6/3