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Turkish Journal of Biology

Abstract

Organ-on-a-chips (OoCs) or microphysiological platforms are biomimetic systems engineered to mimic organ structures onto microfluidic devices for biomedical research. These microdevices can mimic biological environments that enable cell-cell interactions at a small scale by mimicking 3D in vivo microenvironments outside the body. Thus far, numerous single and multiple OoCs that recapitulate organs have been developed, and they have emerged as forerunners for drug efficacy and cytotoxicity testing. This review explores OoC platforms to portray their versatility in investigating drug safety, efficacy, and toxicity. We also reflect upon the potential of OoCs to effectively demonstrate disease models for probable novel therapeutics, which are difficult to achieve in traditional 2D in vitro models, providing an essential basis for biologically relevant research.

Author ORCID Identifier

MUHAMMAD MAAZ KHURRAM: 0009-0007-2117-9897

GÖKTÜRK CİNEL: 0000-0001-5334-7815

ÖZLEM YEŞİL ÇELİKTAŞ: 0000-0003-4509-2212

ERDAL BEDİR: 0000-0003-1262-063X

DOI

10.55730/1300-0152.2711

Keywords

Organ-on-a-chip, microfluidics, biomimetics, drug toxicity screening, drug efficacy screening, disease modeling

First Page

348

Last Page

363

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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