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Turkish Journal of Biology

Abstract

The glioma genome encompasses a complex array of dysregulatory events, presenting a formidable challenge in managing this devastating disease. Despite the widespread distribution of repeat and transposable elements across the human genome, their involvement in glioma's molecular pathology and patient survival remains largely unexplored. In this study, we analysed the expression levels of satellite repeats and transposons along with genes in low-grade glioma (LGG) and high-grade glioma (HGG). Endogenous transposable elements LTR5 and HERV_a-int exhibited higher expression in HGG patients, along with immune response-related genes. Altogether, 16 transposable elements were associated with slower progression of disease in LGG patients. Conversely, 22 transposons and the HSAT5 satellite repeat were linked to a shorter event-free survival in HGG patients. Intriguingly, our weighted gene co-expression network analysis (WGCNA) disclosed that the HSAT5 satellite repeat resided in the same module network with genes implicated in chromosome segregation and nuclear division; potentially hinting at its contribution to disease pathogenesis. Collectively, we report for the first time that repeat and/or transposon expression could be related to disease progression and survival in glioma. The expressions of these elements seem to exert a protective effect during LGG-to-HGG progression, whereas they could have a detrimental impact once HGG is established. The results presented herein could serve as a foundation for further experimental work aimed at elucidating the molecular regulation of glioma genome.

Author ORCID Identifier

SILA NAZ KÖSE: 0000-0003-2358-1605

TUTKU YARAŞ: 0000-0003-3019-7900

AHMET BURSALI: 0000-0001-7050-769X

YAVUZ OKTAY: 0000-0002-0158-2693

CİHANGİR YANDIM: 0000-0002-2050-6186

GÖKHAN KARAKÜLAH: 0000-0001-6706-1375

DOI

10.55730/1300-0152.2700

Keywords

Glioma, HSAT5, repeat, satellite, survival, transposon

First Page

242

Last Page

256

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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