Influence of aerobic exercise training on mice gut microbiota in Parkinson's disease

Authors

TIANLUN FAN
XIATING LI
XIANG ZHANG
JING ZHANG
LICHUN SUN
JINGJING CHEN
CHUAN FU

DOI

10.55730/1300-0152.2617

Abstract

Accumulating evidence shows that gut microbial dysbiosis may represent a risk factor for Parkinson's disease (PD). Exercise has a positive effect on microbiota in general. The effect of aerobic exercise training (AET) on the gut microbial environment in PD remains to be explored. Here, we performed the 16S rRNA gene sequencing on feces from sham operated-mice (sham), PD mice model, and mice receiving AET (AET). Results indicated that AET had no remarkable effect on species richness and bacterial diversity of PD mice. The relative abundance of the Bacteroidetes was reduced, while Firmicutes, Actinobacteria, Lactobacillaceae, Streptococcaceae, Lactobacillus, Streptococcus, Lactococcus, Lysinibacillus, Pelomonas, and Prevotellaceae_UCG?001 were increased in PD mice compared with those of sham operated-mice, whereas AET partly rescued their abundance. Additionally, the composition proportion of beneficial Lactobacillus_gasseri and uncultured_Erysipelotrichales_bacterium significantly increased in AET mice compared to PD mice. Moreover, discriminative bacteria, such as Bacilli, Lactobacillales, Lactobacillaceae, Lactobacillus, and Lactococcus were identified as a specific taxon in AET mice. Here we provide evidence that AET can improve the gut microbiota of PD mice.

Keywords

Parkinson's disease; aerobic exercise training; gut microbiota; 16S rRNA gene sequencing

First Page

288

Last Page

297

Recommended Citation

FAN, TIANLUN; LI, XIATING; ZHANG, XIANG; ZHANG, JING; SUN, LICHUN; CHEN, JINGJING; and FU, CHUAN (2022) "Influence of aerobic exercise training on mice gut microbiota in Parkinson's disease," Turkish Journal of Biology: Vol. 46: No. 4, Article 3. https://doi.org/10.55730/1300-0152.2617
Available at: https://journals.tubitak.gov.tr/biology/vol46/iss4/3