Turkish Journal of Biology
Abstract
Coronavirus disease 2019 (COVID-19) pandemic has been an important global interest that affected millions of people, and it requires a deep investigation of the disease immunology for developing further therapeutic applications. Adoptive T cell therapy promises to address T cell-dependent immune dysregulation in COVID-19 patients by the generation of specific T cell clones against virus-specific antigens. Additionally, targeting B cell-dependent protection through COVID-19 vaccines, which have been developed in the recent year, possessed sufficient prevention for spreading the virus, since the cases and deaths related to COVID-19 tend to decrease after the vaccination. However, adoptive cell therapies are now encouraging scientists to deal with pathological challenges like inadequate T cell-dependent immune response or lymphopenia, since they are the most frequent outcome of severe infection, especially in immunocompromized patients. In this review, the current knowledge of immunopathology of COVID-19 was aimed to be highlighted along with the T cell responses against SARS-CoV-2 to comprise a basis for therapeutics. Moreover, current therapeutics and treatment strategies for COVID-19 were discussed to evaluate possible agents. Furthermore, the use of adoptive T cell therapy representing an emerging therapeutic approach was purposed to be presented comprehensively against SARS-CoV-2 infection. Even though further studies are needed to fully understand T cell response against SARS-CoV-2 in order to develop therapies to provide long term and efficient protection, adoptive cell therapies now meet the demand for a large population of people who suffer immunocompromization, considering the previous usage of the technique for different infectious diseases.
DOI
10.55730/1300-0152.2579
Keywords
Adoptive cell therapy, COVID-19, immunotherapy, SARS-CoV-2, T cell response
First Page
105
Last Page
117
Recommended Citation
TAŞ, SEVGİ KALKANLI; UZUNOĞLU, MERVE SAİDE; UZUNOĞLU, AYLİN SEHER; KIRKIK, DUYGU; ALTUNKANAT, DERYA; and KALKANLI, NEVİN
(2022)
"Adoptive T-cell therapies to overcome T cell-dependent immune dysregulations in COVID-19,"
Turkish Journal of Biology: Vol. 46:
No.
2, Article 1.
https://doi.org/10.55730/1300-0152.2579
Available at:
https://journals.tubitak.gov.tr/biology/vol46/iss2/1