Host Variations in SARS-CoV-2 Infection

Authors

DORUK ALTIOK
ELİF ZEYNEP SAVCI
BÜŞRA ÖZKARA
KAMİL ALKAN
DİLARA SULTAN NAMDAR
GİZEM TUNÇER
BUĞRAHAN REGAİP KILINÇ
EVREN SUİÇMEZ
GÜNEYSU ÇETİN
SİNAN ÜNAL
BEYZA DÖNMÜŞ
ZEYNEP YAĞMUR KARAGÜLLEOĞLU
DİLRÜBA BEYZA UNCUOĞLU
CANSU TEKELİ
HANİFE AYŞEGÜL MENDİ

DOI

10.3906/biy-2104-67

Abstract

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the zoonotic pathogen that causes the "Coronavirus Disease of 2019 (COVID-19)", and COVID-19 itself is yet to be thoroughly understood. Both the disease as well as the mechanisms by which the host interacts with the SARS-CoV-2 have not been fully enlightened. The epidemiological factors -e.g. age, sex, race-, the polymorphisms of the host proteins, the blood types and individual differences have all been in discussions about affecting the progression and the course of COVID-19 both individually and collectively, as their effects are mostly interwoven. We focused mainly on the effect of polymorphic variants of the host proteins that have been shown to take part in and/or affect the pathogenesis of COVID-19. Additionally, how the procedures of diagnosing and treating COVID-19 are affected by these variants and what possible changes can be implemented are the other questions, which are sought to be answered.

Keywords

Angiotensin-converting enzyme 2 (ACE2), host genetics, polymorphisms, SARS-CoV-2, toll-like receptors (TLR), transmembrane serine protease 2 (TMPRSS2)

First Page

404

Last Page

424

Recommended Citation

ALTIOK, DORUK; SAVCI, ELİF ZEYNEP; ÖZKARA, BÜŞRA; ALKAN, KAMİL; NAMDAR, DİLARA SULTAN; TUNÇER, GİZEM; KILINÇ, BUĞRAHAN REGAİP; SUİÇMEZ, EVREN; ÇETİN, GÜNEYSU; ÜNAL, SİNAN; DÖNMÜŞ, BEYZA; KARAGÜLLEOĞLU, ZEYNEP YAĞMUR; UNCUOĞLU, DİLRÜBA BEYZA; TEKELİ, CANSU; and MENDİ, HANİFE AYŞEGÜL (2021) "Host Variations in SARS-CoV-2 Infection," Turkish Journal of Biology: Vol. 45: No. 7, Article 5. https://doi.org/10.3906/biy-2104-67
Available at: https://journals.tubitak.gov.tr/biology/vol45/iss7/5