Turkish Journal of Biology
DOI
10.3906/biy-2006-25
Abstract
MEIS proteins are historically associated with tumorigenesis, metastasis, and invasion in cancer. MEIS and associated PBXHOX proteins may act as tumor suppressors or oncogenes in different cellular settings. Their expressions tend to be misregulated in various cancers. Bioinformatic analyses have suggested their upregulation in leukemia/lymphoma, thymoma, pancreas, glioma, and glioblastoma, and downregulation in cervical, uterine, rectum, and colon cancers. However, every cancer type includes, at least, a subtype with high MEIS expression. In addition, studies have highlighted that MEIS proteins and associated factors may function as diagnostic or therapeutic biomarkers for various diseases. Herein, MEIS proteins and associated factors in tumorigenesis are discussed with recent discoveries in addition to how they could be modulated by noncoding RNAs or newly developed small-molecule MEIS inhibitors.
Keywords
MEIS, cancer, small molecules, MEIS inhibitors
First Page
328
Last Page
355
Recommended Citation
GİRGİN, BİRKAN; ALPASLAN, MEDİNE KARADAĞ; and KOCABAŞ, FATİH
(2020)
"Oncogenic and tumor suppressor function of MEIS and associated factors,"
Turkish Journal of Biology: Vol. 44:
No.
6, Article 1.
https://doi.org/10.3906/biy-2006-25
Available at:
https://journals.tubitak.gov.tr/biology/vol44/iss6/1