Oncogenic and tumor suppressor function of MEIS and associated factors

Authors

BİRKAN GİRGİN
MEDİNE KARADAĞ ALPASLAN
FATİH KOCABAŞ

Abstract

MEIS proteins are historically associated with tumorigenesis, metastasis, and invasion in cancer. MEIS and associated PBXHOX proteins may act as tumor suppressors or oncogenes in different cellular settings. Their expressions tend to be misregulated in various cancers. Bioinformatic analyses have suggested their upregulation in leukemia/lymphoma, thymoma, pancreas, glioma, and glioblastoma, and downregulation in cervical, uterine, rectum, and colon cancers. However, every cancer type includes, at least, a subtype with high MEIS expression. In addition, studies have highlighted that MEIS proteins and associated factors may function as diagnostic or therapeutic biomarkers for various diseases. Herein, MEIS proteins and associated factors in tumorigenesis are discussed with recent discoveries in addition to how they could be modulated by noncoding RNAs or newly developed small-molecule MEIS inhibitors.

DOI

10.3906/biy-2006-25

Keywords

MEIS, cancer, small molecules, MEIS inhibitors

First Page

328

Last Page

355

Recommended Citation

GİRGİN, BİRKAN; ALPASLAN, MEDİNE KARADAĞ; and KOCABAŞ, FATİH (2020) "Oncogenic and tumor suppressor function of MEIS and associated factors," Turkish Journal of Biology: Vol. 44: No. 6, Article 1. https://doi.org/10.3906/biy-2006-25
Available at: https://journals.tubitak.gov.tr/biology/vol44/iss6/1