Single nucleotide polymorphisms in microRNAs action as biomarkers for breast cancer

Authors

THANH THI NGOC NGUYEN
MINH THI HONG TRAN
VY THI LAN NGUYEN
UYEN DOAN PHUONG NGUYEN
GIANG DIEN THANH NGUYEN
LUAN HUU HUYNH
HUE THI NGUYEN

DOI

10.3906/biy-2004-78

Abstract

MicroRNAs (miRNAs) have been recently described as small noncoding RNAs that are involved in numerous crucial physiological processes, such as cell cycles, differentiation, development, and metabolism. Thus, dysregulation of these molecules could lead to several severe disorders, including breast cancer (BC). Ongoing investigations in malignant growth diagnostics have distinguished miRNAs as promising disease biomarkers. As with any other mRNAs, single nucleotide polymorphisms (SNPs) in DNA sequence encoding for miRNA (miR-SNPs) indeed lead to potential changes in the function of miRNA. In this study, miR-SNPs located in different miRNA sequence regions, which have been associated with BC in different ways, and the potential mechanisms of how these miR-SNPs develop the risk of the disease were discussed.

Keywords

Breast cancer, microRNA, miRNA, single nucleotide polymorphism, SNP

First Page

284

Last Page

294

Recommended Citation

NGUYEN, THANH THI NGOC; TRAN, MINH THI HONG; NGUYEN, VY THI LAN; NGUYEN, UYEN DOAN PHUONG; NGUYEN, GIANG DIEN THANH; HUYNH, LUAN HUU; and NGUYEN, HUE THI (2020) "Single nucleotide polymorphisms in microRNAs action as biomarkers for breast cancer," Turkish Journal of Biology: Vol. 44: No. 5, Article 7. https://doi.org/10.3906/biy-2004-78
Available at: https://journals.tubitak.gov.tr/biology/vol44/iss5/7