Turkish Journal of Biology
Abstract
Chordoma is a slowly growing and invasive bone tumor with a tendency to metastasize locally in advanced stages. It is essential to discover new therapeutics that target genes involved in the metastasis of chordoma. Epithelial-mesenchymal transition (EMT) might robustly influence the metastasis of a tumor bulk. To our knowledge, this is the first time to show that EMT might have a role in chordoma metastasis. In this study, we aim to investigate the possible role of Twist, a key player transcription factor of EMT, in chordoma metastasis. The TWIST gene was silenced by short hairpins in chordoma cell line MUG-Chor1 and effects on metastasis were investigated by wound healing/gap closure and invasion assays. Twist-silenced MUG-Chor1 cells were found to be less migratory and less invasive when compared to the negative control. This study indicates that Twist might have a role in metastatic chordoma cells.
DOI
10.3906/biy-1801-17
Keywords
Cancer, epithelial-mesenchymal transition, chordoma, twist
First Page
279
Last Page
285
Recommended Citation
AYDEMİR, E, KAŞIKCI, E, COŞKUNÇELEBİ, B, BAYRAK, Ö. F, & ŞAHİN, F (2018). The effect of TWIST silencing in metastatic chordoma cells. Turkish Journal of Biology 42 (4): 279-285. https://doi.org/10.3906/biy-1801-17
