High-fat diet and glucose and albumin circadian rhythms' chronodisruption in rats

Authors

RAFAEL BRAVO
AMERICO CHINI
LIERNI UGARTEMENDIA
LOURDES FRANCO
MÓNICA MESA
ANA B. RODRIGUEZ
JAVIER CUBERO
CARMEN BARRIGA

Abstract

Obesity is one of the most widespread nutritional diseases in developed societies and it is considered a cardiovascular disease risk factor. The aim of the present work was to evaluate how a high-fat diet may influence the chronobiology of glucose and albumin circadian rhythms. Eighty-four male common Wistar rats were separated into two groups: a control group (n = 42) and a group fed a high-fat diet (n = 42); both for the control and the obesity-induced group we stablished 7 subgroups (6 rats per subgroup) to take blood samples at 0000, 0200, 0400, 1000, 1400, 1800, and 2200 hours. Glucose and albumin plasma levels were analyzed in blood samples and their circadian rhythms were evaluated through the cosinor method. Our results showed clear chronodisruption symptoms in both glucose and albumin oscillations, although these circadian disorders were more evident in glucose rhythms.

DOI

10.3906/biy-1607-74

Keywords

Chronobiology, chronodisruption, obesity, high-fat diet, rats, glucose, albumin

First Page

364

Last Page

369

Recommended Citation

BRAVO, RAFAEL; CHINI, AMERICO; UGARTEMENDIA, LIERNI; FRANCO, LOURDES; MESA, MÓNICA; RODRIGUEZ, ANA B.; CUBERO, JAVIER; and BARRIGA, CARMEN (2017) "High-fat diet and glucose and albumin circadian rhythms' chronodisruption in rats," Turkish Journal of Biology: Vol. 41: No. 2, Article 12. https://doi.org/10.3906/biy-1607-74
Available at: https://journals.tubitak.gov.tr/biology/vol41/iss2/12