Comparison of the osteogenic differentiation capacity of adipose tissuederived mesenchymal stem cells from humans and rats

Authors

SEÇİL ERDEN TAYHAN
ŞEYMA TAŞDEMİR
SAİME İSMET DELİLOĞLU GÜRHAN
EROL MİR

Abstract

Mesenchymal stem cells (MSCs) can be found in many types of adult tissues such as the bone marrow, adipose, placenta, liver, and periosteum. Recently, adipose tissue-derived MSCs (ADMSCs) have become one the most preferred MSC types because of their fast proliferation rate, abundance, and high plasticity for variable cell types. It is known that ADMSCs are able to differentiate into various cells, including osteoblasts, so they are quite promising for orthopedic clinical trials. The present study aimed to compare the osteogenic differentiation conditions of MSCs from human adipose tissue (hADMSC) and those of MSCs from rat adipose tissue (rADMSC). Therefore, differentiation experiments with five different media and two (human and rat) ADMSC types were performed and the mineralization responses of hADMSCs and rADMSCs were different.

DOI

10.3906/biy-1507-128

Keywords

Osteogenic differentiation, mesenchymal stem cell, adipose tissue, human, rat

First Page

1090

Last Page

1095

Recommended Citation

TAYHAN, SEÇİL ERDEN; TAŞDEMİR, ŞEYMA; GÜRHAN, SAİME İSMET DELİLOĞLU; and MİR, EROL (2016) "Comparison of the osteogenic differentiation capacity of adipose tissuederived mesenchymal stem cells from humans and rats," Turkish Journal of Biology: Vol. 40: No. 5, Article 14. https://doi.org/10.3906/biy-1507-128
Available at: https://journals.tubitak.gov.tr/biology/vol40/iss5/14