•  
  •  
 

Turkish Journal of Biology

DOI

10.3906/biy-1507-114

Abstract

The aim of this research was to investigate the effects of the methanol extract obtained from Lycium barbarum fruits on anxiety, depression-like behaviors, and spatial memory in Wistar albino rats. A total of 28 rats were selected, randomly assigned to four experimental groups, and tested by means of the open field and elevated plus maze tests for anxiety-like behaviors, the forced swim test for depression-like behaviors, and the Morris water maze test for spatial memory. The findings demonstrated that in the open field, L. Barbarum-administered rats spent more time at the center and showed more mobility and velocity than controls. In the elevated plus maze, L. Barbarum-administered rats spent more time in the open arms, spent less time in the closed arms, and showed more mobility and velocity. In the Porsolt test, L. Barbarum-administered rats showed less immobility. In the Morris water maze, L. Barbarum-administered rats took more time to find the platform. However, females were better at finding the platform than males. The methanol extract of L. Barbarum fruits decreased anxiety and depression-like behaviors and interacted with sex on spatial memory.

Keywords

Lycium barbarum (goji berry), anxiety, depression, spatial memory, Wistar albino rat (Rattus rattus)

First Page

762

Last Page

771

Download

Included in

Biology Commons

Share

COinS