Effects of amniotic fluid mesenchymal stem cells in carboxymethyl cellulosegel on healing of spontaneous pressure sores: clinical outcome in sevenhospitalized neonatal foals

Authors

ELEONORA IACONO
ALIAI LANCI
BARBARA MERLO
FRANCESCA RICCI
ALESSANDRO PIRRONE
CARLOTTA ANTONELLI
JOLE MARIELLA
CAROLINA CASTAGNETTI

DOI

10.3906/biy-1507-147

Abstract

In the present study, an innovative therapy for spontaneously arisen pressure sores in seven hospitalized neonatal foals is described, using mesenchymal stem cells obtained from equine amniotic fluid. Amniotic fluid mesenchymal stem cells (AFMSCs) were isolated from fluid samples recovered at delivery. Heterologous cells, at passage three of in vitro culture, were applied to sores twice a week for four consecutive times in a carboxymethylcellulose (CMC) gel. As a control, a commercial ointment was used. The results showed that the mean sore regression rate with AFMSCs in CMC gel was statistically higher than the mean value recorded in the control group. This was associated with a significant effect of the treatment used and a statistically significant effect of treatment over time. The results suggest that local application of mesenchymal stem cells isolated from amniotic fluid, using CMC as scaffold, could be considered as an effective treatment of deep sores in hospitalized neonatal foals.

Keywords

Equine, amniotic fluid, mesenchymal stem cells, wound healing, carboxymethylcellulose

First Page

484

Last Page

492

Recommended Citation

IACONO, ELEONORA; LANCI, ALIAI; MERLO, BARBARA; RICCI, FRANCESCA; PIRRONE, ALESSANDRO; ANTONELLI, CARLOTTA; MARIELLA, JOLE; and CASTAGNETTI, CAROLINA (2016) "Effects of amniotic fluid mesenchymal stem cells in carboxymethyl cellulosegel on healing of spontaneous pressure sores: clinical outcome in sevenhospitalized neonatal foals," Turkish Journal of Biology: Vol. 40: No. 2, Article 21. https://doi.org/10.3906/biy-1507-147
Available at: https://journals.tubitak.gov.tr/biology/vol40/iss2/21