S. cerevisiae $\beta$-glucan reduced viability of mouse hepatoma cells in vitro

Authors

ARTUR JAVMEN
AUSRA NEMEIKAITE-CENIENE
SAULIUS GRIGISKIS
IRENA JONAUSKIENE
MARK RUDENKOV
DARIUS KACIANAUSKAS
MYKOLAS MAURICAS

DOI

10.3906/biy-1411-53

Abstract

$\beta$-Glucan is a natural polymer, which is widely studied due to its multiple immunomodulatory properties. In addition, recent findings indicate potent antitumor properties of $\beta$-glucan. Saccharomyces cerevisiae, baker's yeast, is one of the commonly used sources of $\beta$-1,3-glucan. The aim of this work was to investigate S. cerevisiae $\beta$-glucan immunomodulatory activity against cancer cells.In our experiments, BALB/c mice were fed with insoluble whole $\beta$-glucan particles, and then their blood was collected for experiments. MH-22a hepatoma cells were treated with the blood of mice fed with $\beta$-glucan, and tumor cell viability was investigated after the treatment.The obtained results demonstrated that leukocytes in vivoprimed with whole glucan particles, in combination with soluble $\beta$-glucan, decreased MH-22a hepatoma cell viabilityin vitro.Our study has indicated that $\beta$-glucan obtained from S. cerevisiae potentially primes mouse whole blood leukocytes to induce cell death of mouse hepatoma cells.

Keywords

$\beta$-Glucan, yeast, cancer, mice

First Page

562

Last Page

566

Recommended Citation

JAVMEN, ARTUR; NEMEIKAITE-CENIENE, AUSRA; GRIGISKIS, SAULIUS; JONAUSKIENE, IRENA; RUDENKOV, MARK; KACIANAUSKAS, DARIUS; and MAURICAS, MYKOLAS (2015) "S. cerevisiae $\beta$-glucan reduced viability of mouse hepatoma cells in vitro," Turkish Journal of Biology: Vol. 39: No. 4, Article 6. https://doi.org/10.3906/biy-1411-53
Available at: https://journals.tubitak.gov.tr/biology/vol39/iss4/6