Turkish Journal of Biology
Abstract
$\beta$-Glucan is a natural polymer, which is widely studied due to its multiple immunomodulatory properties. In addition, recent findings indicate potent antitumor properties of $\beta$-glucan. Saccharomyces cerevisiae, baker's yeast, is one of the commonly used sources of $\beta$-1,3-glucan. The aim of this work was to investigate S. cerevisiae $\beta$-glucan immunomodulatory activity against cancer cells.In our experiments, BALB/c mice were fed with insoluble whole $\beta$-glucan particles, and then their blood was collected for experiments. MH-22a hepatoma cells were treated with the blood of mice fed with $\beta$-glucan, and tumor cell viability was investigated after the treatment.The obtained results demonstrated that leukocytes in vivoprimed with whole glucan particles, in combination with soluble $\beta$-glucan, decreased MH-22a hepatoma cell viabilityin vitro.Our study has indicated that $\beta$-glucan obtained from S. cerevisiae potentially primes mouse whole blood leukocytes to induce cell death of mouse hepatoma cells.
DOI
10.3906/biy-1411-53
Keywords
$\beta$-Glucan, yeast, cancer, mice
First Page
562
Last Page
566
Recommended Citation
JAVMEN, A, NEMEIKAITE-CENIENE, A, GRIGISKIS, S, JONAUSKIENE, I, RUDENKOV, M, KACIANAUSKAS, D, & MAURICAS, M (2015). S. cerevisiae $\beta$-glucan reduced viability of mouse hepatoma cells in vitro. Turkish Journal of Biology 39 (4): 562-566. https://doi.org/10.3906/biy-1411-53
