Antihyperglycemic, antioxidant and cytotoxic activities of Alocasia macrorrhizos (Linn.) rhizomes extract

Authors

MD MASUDUR RAHMAN
MD. ASLAM HOSSAIN
SAIFUL ALAM SIDDIQUE
KAISHAR PARVEJ BIPLAB
MD. HELAL UDDIN

DOI

10.3906/biy-1112-11

Abstract

Alocasia macrorrhizos (L.) (Araceae), a coarse and erect plant that is widely cultivated to be eaten as a vegetable throughout Bangladesh, has been reported to possess a number of medicinal properties. The antihyperglycemic, antioxidant, and cytotoxic effects of the methanol extract of A. macrorrhizos rhizomes were investigated. The extract was given at a single dose (250 and 500 mg/kg) in alloxan-induced hyperglycemic mice. The extract at 500 mg/kg produced a significant (P < 0.05) decrease in the blood glucose level (55.49%) at 8 h of treatment when compared with the control and was comparable with the reference drug, metformin. The extract was also subjected to antioxidant potentiality and brine shrimp lethality bioassays. The IC_{50} value of the extract was 693.0 \mug/mL and the LC_{50} was 188.14 \mug/mL.

Keywords

Antihyperglycemic, alloxan, Alocasia macrorrhizos, antioxidant activity, cytotoxicity, rhizome

First Page

574

Last Page

579

Recommended Citation

RAHMAN, MD MASUDUR; HOSSAIN, MD. ASLAM; SIDDIQUE, SAIFUL ALAM; BIPLAB, KAISHAR PARVEJ; and UDDIN, MD. HELAL (2012) "Antihyperglycemic, antioxidant and cytotoxic activities of Alocasia macrorrhizos (Linn.) rhizomes extract," Turkish Journal of Biology: Vol. 36: No. 5, Article 11. https://doi.org/10.3906/biy-1112-11
Available at: https://journals.tubitak.gov.tr/biology/vol36/iss5/11