Antihyperglycemic, antioxidant and cytotoxic activities of Alocasia macrorrhizos (Linn.) rhizomes extract

Authors

MD MASUDUR RAHMAN
MD. ASLAM HOSSAIN
SAIFUL ALAM SIDDIQUE
KAISHAR PARVEJ BIPLAB
MD. HELAL UDDIN

Abstract

Alocasia macrorrhizos (L.) (Araceae), a coarse and erect plant that is widely cultivated to be eaten as a vegetable throughout Bangladesh, has been reported to possess a number of medicinal properties. The antihyperglycemic, antioxidant, and cytotoxic effects of the methanol extract of A. macrorrhizos rhizomes were investigated. The extract was given at a single dose (250 and 500 mg/kg) in alloxan-induced hyperglycemic mice. The extract at 500 mg/kg produced a significant (P < 0.05) decrease in the blood glucose level (55.49%) at 8 h of treatment when compared with the control and was comparable with the reference drug, metformin. The extract was also subjected to antioxidant potentiality and brine shrimp lethality bioassays. The IC_{50} value of the extract was 693.0 \mug/mL and the LC_{50} was 188.14 \mug/mL.

DOI

10.3906/biy-1112-11

Keywords

Antihyperglycemic, alloxan, Alocasia macrorrhizos, antioxidant activity, cytotoxicity, rhizome

First Page

574

Last Page

579

Recommended Citation

RAHMAN, MD MASUDUR; HOSSAIN, MD. ASLAM; SIDDIQUE, SAIFUL ALAM; BIPLAB, KAISHAR PARVEJ; and UDDIN, MD. HELAL (2012) "Antihyperglycemic, antioxidant and cytotoxic activities of Alocasia macrorrhizos (Linn.) rhizomes extract," Turkish Journal of Biology: Vol. 36: No. 5, Article 11. https://doi.org/10.3906/biy-1112-11
Available at: https://journals.tubitak.gov.tr/biology/vol36/iss5/11