Turkish Journal of Biology
Abstract
Alocasia macrorrhizos (L.) (Araceae), a coarse and erect plant that is widely cultivated to be eaten as a vegetable throughout Bangladesh, has been reported to possess a number of medicinal properties. The antihyperglycemic, antioxidant, and cytotoxic effects of the methanol extract of A. macrorrhizos rhizomes were investigated. The extract was given at a single dose (250 and 500 mg/kg) in alloxan-induced hyperglycemic mice. The extract at 500 mg/kg produced a significant (P < 0.05) decrease in the blood glucose level (55.49%) at 8 h of treatment when compared with the control and was comparable with the reference drug, metformin. The extract was also subjected to antioxidant potentiality and brine shrimp lethality bioassays. The IC_{50} value of the extract was 693.0 \mug/mL and the LC_{50} was 188.14 \mug/mL.
DOI
10.3906/biy-1112-11
Keywords
Antihyperglycemic, alloxan, Alocasia macrorrhizos, antioxidant activity, cytotoxicity, rhizome
First Page
574
Last Page
579
Recommended Citation
RAHMAN, M. M, HOSSAIN, M. A, SIDDIQUE, S. A, BIPLAB, K. P, & UDDIN, M. H (2012). Antihyperglycemic, antioxidant and cytotoxic activities of Alocasia macrorrhizos (Linn.) rhizomes extract. Turkish Journal of Biology 36 (5): 574-579. https://doi.org/10.3906/biy-1112-11
