Hepatoprotective effect of vitamins C and E against gasoline vapor-induced liver injury in male rats

Authors

FRIDAY EFFIONG UBOH
PATRICK EKONG EBONG
HENRY DAN AKPAN
ITORO FRIDAY USOH

Abstract

The protective effect of vitamins C and E against gasoline vapor-induced liver injury was investigated in rats. Liver injury was assessed from the activities of liver function diagnostic indices including serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase (\gamma-GT), alkaline phosphatase (ALP) activities, total serum protein (TSP), albumin concentrations, and the histological architectures of the liver tissues of the experimental animals. The results showed that gasoline vapors caused a significant (P = 0.05) higher than that of vitamin C. The results of our study suggest a protective effect of vitamin C and vitamin E against gasoline vapor-induced liver injury, with vitamin E as a better option.

DOI

10.3906/biy-1004-111

Keywords

Gasoline vapor, vitamin C, vitamin E, liver enzymes, serum proteins, histopathology

First Page

217

Last Page

223

Recommended Citation

UBOH, FRIDAY EFFIONG; EBONG, PATRICK EKONG; AKPAN, HENRY DAN; and USOH, ITORO FRIDAY (2012) "Hepatoprotective effect of vitamins C and E against gasoline vapor-induced liver injury in male rats," Turkish Journal of Biology: Vol. 36: No. 2, Article 10. https://doi.org/10.3906/biy-1004-111
Available at: https://journals.tubitak.gov.tr/biology/vol36/iss2/10