Anti-inflammatory activity of Anthemis aciphylla var. aciphylla Boiss.

Authors

SİNEM ÖZKAYNAK
HATİCE EFSUN KOLATAN
OSMAN YILMAZ
BİJEN KIVÇAK

DOI

10.3906/biy-1006-15

Abstract

Ethanolic (EEAA) and sesquiterpene lactone (SEAA) extracts of the aerial parts of Anthemis aciphylla var. aciphylla Boiss. (Asteraceae) were evaluated for anti-inflammatory activity on carrageenin-induced paw edema (acute model) and cotton pellet-induced granuloma (chronic model) in rats. In carrageenin-induced paw edema, EEAA and SEAA at intraperitoneal doses of 50, 100, and 200 mg/kg dose-dependently inhibited the paw edema. In cotton pellet-induced granuloma, the oral administration of EEAA and SEAA at 50, 100, and 200 mg/kg dosages was also found to significantly inhibit granuloma tissue formation.

Keywords

Anthemis aciphylla, anti-inflammatory activity, carrageenin, paw edema, cotton pellet

First Page

757

Last Page

762

Recommended Citation

ÖZKAYNAK, SİNEM; KOLATAN, HATİCE EFSUN; YILMAZ, OSMAN; and KIVÇAK, BİJEN (2011) "Anti-inflammatory activity of Anthemis aciphylla var. aciphylla Boiss.," Turkish Journal of Biology: Vol. 35: No. 6, Article 14. https://doi.org/10.3906/biy-1006-15
Available at: https://journals.tubitak.gov.tr/biology/vol35/iss6/14